Published online in Neuron on January 13, the study fills a longstanding gap in understanding the origins of nociceptive-evoked GBOs and their selective relationship with pain processing across ...

Select the journal/section where you want your idea to be submitted: Impacts that threaten or indeed compromise the integrity of tissues trigger the development of a defence response, which through ...

XG005 is a non-opioid, new chemical entity with dual mode of action in targeting both nociceptive and neuropathic pain signals. The placebo, 750 mg or 1250 mg of XG005, was administered orally ...

Unlike nociceptive pain, NP does not respond to usual analgesics such as paracetamol and non-steroidal anti-inflammatory drugs. Entrapment neuropathy, peripheral neuropathy or small-fibre neuropathy ...

The neurobiological processes involved in corneal symptoms of dry eye (DE) and neuropathic corneal pain (NCP) have not been clearly considered in terms of nociceptive processing. The conventional ...

The classification of chronic pain falls into three broad categories: pain owing to tissue disease or damage (nociceptive pain, such as osteoarthritis), pain caused by somatosensory system disease or ...

This TENS-induced non-noxious afferent input produces synaptic inhibition of nociceptive cell activity in the central nervous system. Although the use of TENS is widespread, its clinical ...

The prevalence of FM has been estimated at 2-7% in general population, but 10-30% patients with several rheumatic diseases fulfill the FM criteria, which suggests that they have not only nociceptive ...

To account for incomplete cross-tolerance, we further reduce the calculated dose by 30%. Results The majority of patients had mixed nociceptive-neuropathic pain (83%) and the predominant reason for ...