Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...

One notable exception is the cyclin-dependent kinase inhibitor p27 Kip1 ... Normally p27 resides in the nucleus, but in these tumors it can be found instead in the cytoplasm.

Mutations occur to this DNA in the same way as DNA found in the nucleus, but studying ... The researchers found that by blocking the kinase "off switch" of pyruvate dehydrogenase, they could ...