Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

TNFRSF11A encodes the receptor activator of NFκB (RANK), which is critical for normal osteoclast formation; genetic variants in this gene result in familial expansile osteolysis, a Paget-disease ...

The findings, published recently in JCI Insight, reveal that circulating osteoclast precursor cells (cOCPs) play a pivotal role in bone loss. The study is also the first of its kind to establish a ...

Abstract: The mechanism by which bone collagen and other organic components are degraded by the osteoclast during osteoclastic bone resorption was unclear until the 1980s. Studies conducted since the ...

This ligand and M-CSF are now known to be essential for osteoclast differentiation from marrow and circulating precursors. This study examined whether OPGL and its soluble receptor osteoprotegerin ...

Additionally, in vitro studies detected that miR-335-3p is important for osteoclast differentiation, with its direct targeting site in Fos. Further studies demonstrated Fos was upregulated in CUMS ...

However, it remains unclear whether NETs and their carbamylated protein cargo directly promote bone destruction and alter osteoclast biology. Methods NETs and carbamylated NETs (cNETs) were assessed ...

Magnetic Field,Bone Resorption,Magnetic Flux,Magnetic Force,Osteoclast Formation,Static Magnetic Field,48-h Culture,Acid Phosphatase,Biomechanical Properties,Bone ...