TNFRSF11A encodes the receptor activator of NFκB (RANK), which is critical for normal osteoclast formation; genetic variants in this gene result in familial expansile osteolysis, a Paget-disease ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

The findings, published recently in JCI Insight, reveal that circulating osteoclast precursor cells (cOCPs) play a pivotal role in bone loss. The study is also the first of its kind to establish a ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements. The structural integrity of bones has been attributed to bone remodeling—a ...

Hayata and Yasuhiro Arasaki from TUS tackled these knowledge gaps. Motivated by the intricate and complex process of osteoclast differentiation, they sought to more thoroughly understand how the ...