Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that ...

osteoclasts and osteoblasts. Current therapies for the prevention and treatment of osteoporosis are limited by efficacy and patient compliance. RANKL/osteoprotegerin/RANK signaling regulates bone ...

The Parathyroid Hormones: Bone-Forming Agents for Treatment of Osteoporosis ... In addition, the osteoblasts turn off the gene for the osteoclast-suppressing OPG. Now the balance shifts from ...

They observed that Fam102a promoted the differentiation of both osteoclasts and osteoblasts, and deletion of Fam102a resulted in an osteoporosis-like condition in mice, characterized by low bone ...

Osteoporosis ... with new tissue created by cells called osteoblasts; bone begins to weaken when bone resorption exceeds bone formation. Circulating osteoclast precursor cells exacerbate bone ...

They are somewhat farther a field, but there are, there's a drug that talks to the chemical that signals those bone eating cells, the osteoclasts, to block that signal, and that's something you ...

iSN40 effectively blocks the formation of osteoclasts, which play a critical role in osteoporosis development," says Dr. Takaya. Further experiments in a co-culture system with osteoblasts and ...