Inhibition of PCSK9 suppressed breast cancer metastasis in multiple models. Germline mutations are hereditary and affect every cell in the body. Because primary and metastatic tumours from the ...

1月10日，恒瑞医药的一款抗PCSK9药物瑞卡西单抗获国家药监局批准上市，成为最新一款获批上市的国产靶向PCSK9的降脂药物。此前，已有6款PSCK9药物 ...

PCSK9抑制剂的使用正在为临床上难治性高胆固醇血症以及他汀类药物不耐受的患者群体开辟全新的治疗前景。 1月10日，恒瑞医药的一款抗PCSK9药物瑞 ...

近年来，一种新型降脂药物——PCSK9抑制剂进入临床应用，药物通过皮下注射的方式给药，具有长效性和便捷性的优势，可以每2周到每6个月注射一次 ...

对此，近年来备受瞩目的PCSK9单抗类药物与他汀类药物的联合治疗方案应用越来越广泛，但在给药频率上仍存在一定局限性，患者需要每日服用他汀 ...

AstraZeneca has reported the first clinical data with its oral PCSK9 inhibitor AZD0780, which it hopes could offer an alternative to current injectable drugs used to lower cholesterol. The new ...

He counters this objection by citing the example of PCSK9, a gene that codes for a protein that regulates cholesterol levels in the bloodstream. “Very few people have mutations in the PCSK9 gene ...

The three main known genetic mutations in FH impact LDLR (most common), APOB (apolipoprotein B, about 10% of FH cases), or ...

AstraZeneca has bought rights to an orally-active drug that inhibits PCSK9, offering a patient-friendly alternative to current cholesterol-lowering therapies that have to be delivered via a needle.

But new research suggests an alternative mechanism has been overlooked-;elusive mutations driving metastasis ... A common variant of the PCSK9 gene immediately caught their attention.