By Dr. Sanchari Sinha Dutta, Ph.D. New research uncovers how distinct molecular profiles and immune signatures in metastatic ...

Targeting this particular type of innate immune cells or interfering with ... macrophages restores tumor immunity and inhibits PDAC metastasis." Key contributor Professor Ainhoa Mielgo commented ...

In the current study, scientists generate and analyze genomic, transcriptomic, and T-cell receptor sequencing data of metastatic PDAC patients to explore molecular and immune differences between ...

An enzyme called MICAL2 promotes tumor growth and metastasis in the most common form ... and spread in pancreatic ductal adenocarcinomas (PDAC), the most common form of pancreatic cancer.

In a new study, researchers at the University of California San Diego School of Medicine have discovered that an enzyme called MICAL2 promotes tumor growth and spread in pancreatic ductal ...

Further analyses indicated that IL-1 blockade prevented the trafficking of inflammatory immune cells such as neutrophils to the tumor, which promoted cancer progression. Additionally, in a clinical ...

Toward this end, we have developed a set of unique techniques and experimental models that allow us to inspect, extract, and monitor microscopic metastases in bone. The immune system is the major ...

We are interested in metastasis, the cause of 90% of cancer deaths. The lab investigates metastatic stem cells and their stromal niches. The role of immune regulatory and regenerative signals, ...