In addition, inhibitors of the PI3K pathway could be tested in combination with EGFR inhibitors in patients that do not express PTEN. –JCL Cross-talk between glutamate receptors and acid-sensing ...

called phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and a widely studied pro-tumorigenic transcription factor, called androgen receptor (AR). However, no therapies exist to ...

Fatty liver disease, the excessive lipid accumulation in the liver, is a frequent metabolic condition that can progress in cancer. Despite years of research, targeted treatments are still lacking and ...

increased cell signaling from other HER receptors, increased Akt activity, reduced PTEN level, reduced p27kip1, and increased IGF-IR signaling There is an urgent need to identify biomarkers to ...

called phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and a widely studied pro-tumorigenic transcription factor, called androgen receptor (AR). However, no therapies exist to ...

Additionally, loss of function of the tumor suppressor PTEN gene, the negative regulator ... Decreased interaction between trastuzumab and its target receptor HER2, which is due to steric ...

called phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and a widely studied pro-tumorigenic transcription factor, called androgen receptor (AR). However, no therapies exist to ...

In addition to this, we also assessed the prognostic values of these alterations, and specifically in the HER2-positive breast cancer brain metastasis, we observed that the presence of PIK3CA ...

Given the link between CDK12 loss and castration resistance in human PCa, investigators analyzed androgen receptor (AR ... the growth of tumors devoid of PTEN. Loss of CDK12 inactivated TRP53 ...