Although β cells are clearly derived from progenitor cells during embryonic development, these pancreatic ... that β-cell proliferation, rather than stem cell differentiation, is the dominant ...

NKX2.2 not detected in pancreatic progenitors before endocrine commitment Differentiation of the acinar lineage Nkx6.1 excluded from tip cells by e14.5 (CS19–20) (13) NKX6.1 still detected in ...

is thought to stimulate islet neogenesis by triggering the differentiation of pancreatic progenitor cells. So far, preclinical studies have reported that Pancreate increased insulin production in ...