“In the study, we showed that PACAP neurons in the lateral parabrachial nucleus extensively receive inhibitory input from the central nucleus of the amygdala,” said Han. “So, our next question ...

PACAP is a neuropeptide involved in stress regulation, and the authors studied neurons in a part of the brain called the parabrachial nucleus that produce PACAP and project to the dorsal raphe ...

In a study, appearing in the journal Pain, they found that a brain region called the lateral parabrachial nucleus (LPBN) plays a key role in driving this phenomenon. When LPBN neurons were ...

From there, the researchers traced the signal across the synapse to spinoparabrachial neurons, which carried the signal up the spinal cord to the parabrachial nucleus (PBN), a brainstem region ...

Key findings show the lateral parabrachial nucleus significantly influences pain processing and response while signals from the lateral hypothalamus can reduce pain responses. These insights could ...

Arnab Barik and his colleagues at the Indian Institute of Science (IISc), Bangalore, have shown that cells in the lateral parabrachial nucleus (LPBN), a critical hub of the brain’s pain circuits, ...