A long series of experiments, beginning in 1956 and ending around 1980, established an outline of cell wall structure and demonstrated that penicillin inhibited one of the terminal steps in its ...

The beta-lactam ring portion of the antibiotic targets the penicillin-binding proteins (PBP), found in the bacterial cell membrane, which function in the synthesis of the cell wall. Binding of the ...

Bacteria detect cell wall fragments as danger signals and form protective biofilms, a survival strategy seen across species ...

The various cellular pathways that antibiotics inhibit, which include the synthesis of the cell wall and macromolecules such as DNA, RNA, proteins and folic acid, have been pinpointed by researchers.

Amoxicillin binds to penicillin-binding proteins within the bacterial cell wall and inhibits bacterial cell wall synthesis. Clavulanic acid is a beta-lactam, structurally related to penicillin ...