2008; Daub et al., 2008). Gygi's group looked at phosphorylation changes across the proteome in the mitotic and G 1 phases of the HeLa cell cycle, using stable isotope metabolic labeling to enable ...

The cell cycle is regulated by a number of important protein families which are common targets for mutational inactivation or overexpression in human tumours. The cyclin D and E families and their ...

Esophageal squamous cell carcinoma (ESCC) is a severe health threat, being a predominant subtype of esophageal cancer and contributing significantly to cancer-related mortality globally. Despite ...

Thanks to Rice researchers' new findings, however, phosphorylation-based innovations in "smart cell" engineering could ... set out to prove—was that each cycle in a cascade can be treated ...

what the cell does in response phosphorylation is a sequential process that develops as a sequence of interconnected cycles. Each cycle in a cascade can be viewed as an elementary unit ...

Aberrant cell cycle regulation leads to cancer development ... More recently, I discovered that Fbw7 regulates the degradation of c-Jun in a GSK-3 phosphorylation dependent manner. My results assign a ...