HIV-1是导致全球艾滋病流行的主要致病病毒，深入探究其感染机制是开发有效治疗策略的关键。HIV-1感染的核心步骤之一是将其遗传物质运输到宿主细胞核内，并成功整合到宿主的基因组中。然而，宿主细胞核由双层膜包裹，只有核孔复合体（nuclear pore ...

Cargo molecules are transported through nuclear pore complexes (NPCs). Small molecules can pass by diffusion, but there is a permeability barrier for larger molecules, with a relative molecular ...

Supercomputer simulations have revealed how changes in the shape of the HIV-1 capsid protein may help the virus squeeze its ...

And for successful infection, it has to ultimately open up and release the viral genetic information into the host cell. Nuclear pore complexes are the guardians of the human genome that is ...

Combining experiments in microfluidic devices and computer simulation, this study provides a valuable analysis of the relevant parameters that determine the motility of (multicellular) magnetotactic ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

The implant attracts diseased immune cells, enabling researchers to study and target them with a nanoparticle-based treatment The design of the ...

Several gasdermin-D proteins will link together to create a round pore on the cell, like a hole punched in a balloon. The cell's contents leak out, the cell collapses, and dies. But the collapse ...