DNA replication is one of the most basic processes ... Meanwhile, as the helicase separates the strands, another enzyme called primase briefly attaches to each strand and assembles a foundation ...
Without a connecting link, the CMG complex could just "run off" and leave pol-a/primase behind. This would create long regions of vulnerable ssDNA. Therefore, the second rule in DNA replication is ...
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...
This process is essential for the proper functioning and survival of all living organisms. DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division.
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