By examining keratinocytes from donors of different ethnicities and ages, the researchers identified the PTGS2/PGE2/EP4 pathway as a key driver of this escape process. The researchers show that ...

Next, we will elaborate on this pathway. What Systems Do These Signaling Molecules Activate? The eicosenoids — prostaglandins, thromboxanes, and leukotrienes — are universally produced ...

Recent advancements in understanding the molecular basis of the prostaglandin D2 receptor ... activates DP2 through the Gαi signaling pathway, while indomethacin preferentially activates the ...

But the process is not only electrical. When you get injured -- say with a sprain -- the damaged tissue releases chemicals called prostaglandins, which are like hormones. These prostaglandins ...

Microsomal prostaglandin E synthase-1 (mPGES-1 ... 1 and modulating macrophage polarization through specific cellular pathways[1]. This compound not only decreased levels of inflammatory markers ...

Endogenous prostaglandins (PGs) and their receptors are found in the aqueous humor drainage pathways. Endogenous PGs biochemically regulate the matrix metalloproteinases and tissue inhibitors of ...

Peripheral T-cell lymphoma (PTCL) is an aggressive tumor derived from mature T cells and natural killer cells with an extremely poor prognosis. Ferroptosis is a mechanism of cell death that is ...