Figure 1: Normal LMP2 expression and proteasome function in NOD mice. Castano, L. & Eisenbarth, G.S. Type-I diabetes: a chronic autoimmune disease of human, mouse ...

But rather than the scavengers and microbial decomposers at work in macroscale habitats, much of the protein recycling work within the cell falls to a barrel-shaped protein complex known as the ...

The proteasome, the cell's garbage disposal mechanism ... The researchers speculate that its secondary function in dorsal root ganglion neurons, which transmit sensory signals from skin-proximal ...

The company's focus is on creating small-molecule therapeutics that enhance the natural function of proteasomes, the cellular ...