Figure 1: Normal LMP2 expression and proteasome function in NOD mice. Castano, L. & Eisenbarth, G.S. Type-I diabetes: a chronic autoimmune disease of human, mouse ...

In this study, we show that these inclusions stain positively for the 20S proteasome and the molecular chaperone HDJ-2/HSDJ. Similarly, HeLa cells transfected with mutant ataxin-1 develop nuclear ...

The company's focus is on creating small-molecule therapeutics that enhance the natural function of proteasomes, the cellular ...

The proteasome, the cell's garbage disposal mechanism ... The researchers speculate that its secondary function in dorsal root ganglion neurons, which transmit sensory signals from skin-proximal ...