Subsequently, a reactivity function forms a covalent bond ... tool for the isolation of staurosporine-binding kinases from complex protein mixtures. The specificity of the assay is demonstrated ...

Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout ...

Kinases are proteins involved in many different important cellular functions. "The genome of most mammals, including humans, contains about 500 protein kinases that regulate most aspects of our ...

What is ALPK2, and how can it help treat heart failure? Researchers have found that this heart-specific enzyme may prevent ...

Kinases are proteins involved in many different important cellular functions. "The genome of most mammals, including humans, contains about 500 protein kinases that regulate most aspects of our ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

is one of a group of proteins called kinases. Kinases are enzymes which modify their targets to regulate many cell functions; they are commonly dysregulated in diseases such as cancer, making them ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to maintain a protein phospohorylation balance required for normal cell function. If this balance is disrupted, the outcome may be ...

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family ...