Base-pair sequence-alignment programs differentially handle ... twice as much non-coding constrained sequence compared with protein-coding regions. Margulies, E. H., NISC Comparative Sequencing ...

It relies on an older bioinformatics construct called multiple sequence alignment (MSA), in which a protein’s sequence is compared to evolutionarily similar proteins in order to deduce its ...

For the first time, researchers used data from protein shapes and combined it with data from genomic sequences to improve the reliability of evolutionary trees—which they describe as a critical ...

Bioinformatics approaches including Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), Molecular Operating Environment (MOE), and iCn3D software were used to compare protein ...

Proteins have evolved to minimize energetic ... enhancing the energetic frustration features in the input multiple sequence ...