Moreover, advancements in technology, such as single-cell RNA sequencing and CRISPR ... single gene to produce multiple mRNA isoforms by using different polyadenylation sites, affecting gene ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative ... functional consequences of the divergent isoforms expressed from ...

Now, a group at Osaka University has shed some light on this phenomenon, by combining two different RNA sequencing techniques ...

Regarding post-translational modifications, the authors catalogued alternative polyadenylation, which affects transcript length and stability, as well as adenosine to inosine RNA editing. Inosines are ...

At first glance, polyadenylation isn't an obvious culprit in cancer. It is an evolutionarily ancient and routine process that adds a tail of RNA nucleotide "letters"—all of them adenosines ...

Grozdanov explained that alternative polyadenylation is an RNA-processing mechanism that determines how an mRNA amino acid sequence ends by selecting specific sites called polyadenylation sites.