RNA vaccines are composed of the nucleic acid RNA, which encode antigen genes of an infectious agent. When administered to host cells, the RNA is translated into protein antigens that elicit ...

A recent study published in Nature Communications by researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and collaborators evaluated a replicating RNA (repRNA) vaccine ...

As a now-proven vaccine technology ... best-in-class RNA polymerases for mRNA synthesis by in vitro transcription (IVT) (Fig. 1). Primrose Bio’s Prima RNApols offer significantly higher mRNA ...

The team’s RNA-LNP approach – described in the journal Cell – works by reprogramming the TME using a sample of the tumour itself, so it can work both as a vaccine to stimulate an immune ...

Scientists outside the vaccine manufacturing field frequently use sequencing to analyze aspects of DNA and RNA biology, including gene expression, RNA polyadenylation or poly(A) tails, and ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

This was problematic because these molecules are used as starting material for in vitro transcription RNA production. “Adding a more retentive post-column composed of a more classical C18 ...

RNA Synthesis (Transcription) The genetic information stored in DNA is transcribed into RNA ... Gene therapy holds promise for treating genetic disorders, cancer, and other diseases. Nucleic acid ...

Even non-scientific Israelis recognize the term “mRNA” (messenger RNA) from the COVID-19 vaccines that they ... the title “Cell-type-specific mRNA transcription and degradation kinetics ...

Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA- dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site.