the antisense strand has to be incorporated into the RNA-induced silencing complex (RISC). It turns out that the relatively low thermodynamic stability in the 5′ end of the antisense siRNA ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Mol. Cell 53, 606-616. Eubacterial Argonaute Enzymes. Ago proteins constitute a key component of the RNA-induced silencing complex (RISC), contributing to both the architectural and catalytic ...

Benitec has a market cap of $250mn, $67.8mn in cash, and a cash runway of over 10 quarters, but faces risks due to its small ...

Only one strand of the miRNA:miRNA* duplex or the siRNA duplex is preferentially assembled into the RNA-induced silencing complex (RISC) , which subsequently acts on its target by translational ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...