Methotrexate (MTX) remains a cornerstone in the treatment of rheumatoid arthritis ... pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.
ALLAN GIBOFSKY: In rheumatoid arthritis ... or pathway in the inflammatory process they block. Many biologics target cytokines that can trigger inflammation or are responsible for signaling ...
Moreover, increased type I interferon signaling ... Rheumatoid arthritis (RA) is an autoimmune disease characterized by ...