A key discovery was the activation of the HIF1α-HMOX1 axis, which drives excessive autophagy and ferritin degradation, leading to intracellular iron overload and lipid peroxidation, hallmarks of ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

The study also raises the possibility of exploring the autophagy-ferroptosis axis in other cancers that metastasize to the bone. Dr. Aline Bozec, the lead investigator of the study, commented ...

The study also raises the possibility of exploring the autophagy-ferroptosis axis in other cancers that metastasize to the bone. Dr. Aline Bozec, the lead investigator of the study, emphasized the ...