High serum transaminases usually result from hepatocyte necrosis associated with acute viral infections, toxic or ischemic injury. By contrast, there is normal-to-moderate elevation of ...

The updated prescribing information states that hepatotoxicity has occurred in the postmarketing setting and encourages hepatic laboratory tests -- including serum alanine transaminase ...

Obtain urinalyses, serum electrolytes to evaluate renal tubular function. Measure serum transaminases, bilirubin before initiating therapy then every 2 weeks during 1 st month, then monthly.