Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...

ERBB receptors ... ERBB receptor in the cell. Although HSP90 is a protective chaperone for all ERBB receptors, it can actually influence the function of one ERBB. This interaction was discovered ...

The ERBB receptors ... ERBB Receptors Ligand binding to the extracellular domain, which is the portion of the receptor on the outside of the cell, leads to several events. One is receptor ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors ... aGPCR is that a ligand from outside the cell attaches to one of the extracellular ...

Epidermal growth factor receptor (EGFR) is a major driver of cancer dissemination and target for anti-cancer therapies but ...

SMFS allows the direct measurement of the strength and kinetics of receptor-ligand interactions at the single-molecule level ... such as antibody-antigen interactions and cell adhesion. SMFS has ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

Bioinformatics allowed me to address these questions faster and with a broader perspective. The growing availability of public data facilitated this. However, the transition wasn’t easy. I tried many ...