Small GTPases of the Rho family are potent modulators of the actin and microtubule cytoskeleton. Recent data indicate that the Ras-like RAP1 protein and various Rho proteins crosstalk to polarity ...

which are activated by G protein–coupled receptors (GPCRs) and consist of alpha, beta, and gamma subunits, and the monomeric small G proteins, which belong to the Ras superfamily of small GTPases.