Sorafenib is an oral multikinase inhibitor that inhibits tumor growth and proliferation by interfering with several receptor tyrosine kinases involved in the pathogenesis and perpetuation of ...

Chemotherapeutic agents are often used to treat cancer. They combat tumor growth, but also have a number of undesirable side ...

Some SMIs such as sorafenib are multiple receptor inhibitors. Sorafenib was developed as a Raf kinase inhibitor, targeting the Ras-Raf-MEK-ERK pathway; but was subsequently discovered to target ...

Merck & Co/MSD has won approval in the US for PD-1 inhibitor Keytruda as a treatment ... after or were refractory to Bayer’s Nexavar (sorafenib), the first-line standard of care for HCC.

an algorithm was proposed for monitoring, prevention, and treatment in the context of cardiotoxicity, including the VEGFR inhibitors sunitinib and sorafenib. In sum, my main criticism of the ...