This finding emphasizes the need for a nuanced approach to pain management that considers the timing and type of treatment administered. Research has also uncovered the role of spinal microglia ...

The pain is frequently resistant to NSAIDs and opioids, and many patients more than 20 millions in the world are in distress. We have discovered that brain immunocompetent cell microglia have very ...

Mounting evidence points to a role of spinal neuroimmune dysregulation in the pathogenesis of neuropathic pain. Studies in animals suggest that pre-emptive suppression of microglial (and astrocyte ...

"Using experimental tools to deplete microglia, we found it's possible to prevent abnormal nerve growth, and prevent ...

More information: Faith H. Brennan et al, Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice, Science Translational Medicine (2024). DOI: 10.1126 ...