May be antagonized by concomitant (within 30 minutes) sumatriptan nasal spray. Sedation, dizziness, nasal congestion, insomnia, GI upset, respiratory depression, sweating, hypo- or hypertension ...

circadian changes in absorption from the nasal mucosa or in the metabolism and elimination of butorphanol related to inactivity during the night. The impact of variability in blood collection ...

A physician administered the nasal spray and attempted to concentrate ... and nonprescription drugs that might interact with butorphanol metabolism or nasal physiology from the date of screening ...