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Immunity | 德州农工李平卫团队揭示cGAS-STING 通路第二信使cGAMP跨膜转运 ...
病毒感染会引起强烈的先天免疫反应,诱导干扰素等细胞因子的表达,进而抑制病毒在细胞内的扩增。cGAS-STING信号传递通路是细胞内DNA感应的重要机制,在先天免疫反应过程中起到重要作用。cGAS被DNA激活后,催化合成第二信使环二鸟腺苷酸(cycli ...
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