Traditionally, therapies combining DNA-damaging agents and STING agonists have shown potential in treating cancer by enhancing immune response and reshaping the tumor microenvironment. However ...

The dosing of patients with advanced sarcoma and Merkel cell carcinoma by intravenous infusion of Curadev's systemic allosteric STING agonist, CRD3874-SI, has been initiated in a Phase 1a/b dose ...

In 2013, a synthetic STING agonist, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), showed tremendous anticancer efficacy in mice but failed in human clinical trials because the murine and human ...

The fatality is considered to be related to the drug treatment, according to the biotech, which is developing the STING agonist in collaboration with GSK under the terms of a $1.3 billion option ...

The activation of the intracellular transmembrane receptor stimulator of interferon genes (STING) has shown antitumoral effects in murine cancer models.

PtII物种杀死肿瘤细胞，导致释放DNA片段激活DCs中的STING，同时由自由MSA-2放大he。DCs中的STING激活促进IFN-β分泌，激活CD8+ T和NK细胞，释放IFN-γ和GzmB ...

Mukesh Ambani lauds PM Modi's vision for self-reliance in energy sector, says no power can stop India's growth trajectory ...