16). We tested the hypothesis that mutant APP causes age-dependent learning impairment through disruption of synaptic plasticity. Figure 2: LTP is impaired in the dentate gyrus in aged APP 695 SWE ...

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The researchers determined that when these synapses are stimulated, they undergo long-term strengthening and weakening of ...

The group focuses on studying the mechanisms guiding activity-dependent development of glutamatergic circuitry in the limbic system and in particular, the roles of ionotropic glutamate receptors in ...

The British Library's UK Web Archive has archived the pages. Visit the last archived version of the Centre for Synaptic Plasticity webpages.

Neuromorphic computing is an emerging computing technology inspired by the operational principles of the human brain. By ...

They receive thousands of synaptic signals via their dendrites, with individual synapses undergoing activity-dependent ...

We have shown that intrinsic excitability changes after induction of synaptic plasticity. We have shown that intracellular calcium dynamics also changes after induction of synaptic plasticity. We ...