Using cryo-electron tomography, the team was able to visualize synaptic vesicles (SVs) in 3D and confirm a potentially important protein-protein interaction. They also broadened our understanding ...

A new study published in JAMA Psychiatry provides evidence that young adults at risk of developing psychosis show reduced ...

They also broadened our understanding of SV function and of how the vesicles are recycled. The study was published in the Proceedings of the National Academy of Sciences (PNAS.) “Synaptic ...

Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain.

(3) This causes synaptic vesicles to fuse with the terminal membrane, releasing neurotransmitter into the gap between neurons, known as the synaptic cleft. (4) The neurotransmitters bind to ...

To do this, the synaptic vesicle must dock at the membrane of the presynaptic neuron and dump its content into the synapse, where it moves to particular receptors on the postsynaptic neuron.

Synaptic vesicle docking and fusion are mediated by the assembly of a stable SNARE core complex of proteins, which include the synaptic vesicle membrane protein VAMP/synaptobrevin and the ...

Alterations in trafficking of synaptic vesicles, and a drop in surface levels of critical pre- and post-synaptic receptors, seemed to blame (image below). Could changes in endolysosomal trafficking ...

Characterizing zinc signaling in human hippocampal neurons differentiated from stem cells. Developing a FRET sensor for synaptic vesicle zinc. Currently Funded by the CU Signaling and Cellular ...

To do this, the synaptic vesicle must dock at the membrane of the presynaptic neuron and dump its content into the synapse, where it moves to particular receptors on the postsynaptic neuron.