在一项新的研究中，德国马克斯-德布吕克分子医学中心原位结构生物学实验室组长Misha Kudryashev教授及其同事们揭示了突触小泡（synaptic vesicle ...

Synaptic vesicle docking and fusion are mediated by the assembly of a stable SNARE core complex of proteins, which include the synaptic vesicle membrane protein VAMP/synaptobrevin and the ...

Using cryo-electron tomography, the team was able to visualize synaptic vesicles (SVs) in 3D and confirm a potentially important protein-protein interaction. They also broadened our understanding ...

They also broadened our understanding of SV function and of how the vesicles are recycled. The study was published in the Proceedings of the National Academy of Sciences (PNAS.) “Synaptic ...

A new study published in JAMA Psychiatry provides evidence that young adults at risk of developing psychosis show reduced ...

Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain.

近期， 中国科学院 生物与化学交叉研究中心刘聪课题组和美国辛辛那提大学医学院刁佳杰课题组在 eLife 上合作发表了一篇题为 “N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine” 的研究论文 ...

(3) This causes synaptic vesicles to fuse with the terminal membrane, releasing neurotransmitter into the gap between neurons, known as the synaptic cleft. (4) The neurotransmitters bind to ...

Developing a FRET sensor for synaptic vesicle zinc. Currently Funded by the CU Signaling and Cellular Regulation Training Program. I love working with neurons and understanding their basic mechanisms.

Alterations in trafficking of synaptic vesicles, and a drop in surface levels of critical pre- and post-synaptic receptors, seemed to blame (image below). Could changes in endolysosomal trafficking ...