在众多的TCR研究方法中，NGS技术逐渐成了TCR主流的分析方法。但市面上TCR-Seq的方法琳琅满目，每种方法之间的细微差别也会使得实验结果大不同。所以如何选择合适的方法成为摆在研究人员面前的难题。巴黎索邦大学的Barennes团队 1 评估了市面上9种TCR-Seq方法 ...

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The diversity of the TCR repertoire, however, means that sequencing is technically challenging, particularly for samples with low-quality, degraded nucleic acids. Current methods have significant ...

"Overall, ATLAS-seq improves TCR screening to more effectively identify antigen-reactive TCRs with high functional activity." The ATLAS-seq technology combines a single-cell approach with an ...

"In this study, we asked whether the RNLS protein could potentially be a tumor antigen by examining chemical complementarity ...

The ATLAS-seq technology combines a single-cell approach ... by an antigen peptide of interest and determined their unique TCR sequences using single-cell sequencing. This work was supported ...