Prolonged rapid eye movement (REM) sleep latency was linked with Alzheimer's disease biomarkers, cross-sectional data showed.

including β-amyloid deposits and amyloid plaques, neuritic dystrophy, astrogliosis, reactive microgliosis and abnormal tau phosphorylation 13,14,15. In additional to structural and neurochemical ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

"If you can reduce tau phosphorylation ... slow-wave sleep and elevated levels of tau tangles and amyloid-beta protein. In this latest study, Lucey and colleagues wanted to find out if improving ...

This line of inquiry follows animal model and stem cell studies in which efavirenz reduced the accumulation of both amyloid beta and tau. It’s hypothesized that accumulation of cholesterol in ...

Seventeen clinical scenarios developed for which amyloid or tau PET may be considered. HealthDay News — Appropriate use criteria (AUC) for the use of amyloid and tau positron emission tomography ...

Why have the previous anti-tau therapies shown limited efficacy in vivo? For decades, researchers have produced numerous AD drugs targeting amyloid beta only for them to fail in clinical trials.

Some researchers believe the brain makes Aβ to help fight bacterial and fungal invaders. Now comes evidence that p-tau may take on a similar role against viruses. In the January 2 Cell Reports, ...

“The discovery that tau phosphorylation can act as a protective ... investigate other pathogens that might interact with tau (or [beta-amyloid]) in Alzheimer’s, and test potential therapies ...

Louis found taking suvorexant, a common insomnia medication, for two nights slightly decreased amyloid-beta and tau proteins linked to Alzheimer's. Researchers suggest improving sleep may help ...