Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

IL-6, combined with TGF-β, preferentially induces the differentiation of naive CD4-positive T cells into Th17 cells, whereas IL-6 inhibits TGF-β-induced Treg development. As a consequence ...