More recently, ST2L has been shown to participate in activation of antigen-primed Th2 cells. ST2 has been implicated in numerous inflammatory conditions such as asthma, fibroproliferative diseases ...

These Tregs travel to the lung draining lymph nodes and protects the host from allergen-mediated allergic asthma by blocking Th2 cells.

which are early source of IL-4 to assist DCs for Th2 polarization. Controlling the activity of basophils can be therapeutically beneficial in early stage asthma. This work was supported by NIH ...

Established in 2022, the partnership is centred on the manufacturing of a cGMP 2000L drug substance commercially.

Chime Biologics, a global CDMO, and Mabgeek, a clinical-stage innovative antibody drug development biotech, have successfully ...

Within the next year, KP-723 is expected to enter several Phase I trials in AD and may have applications in other Th2-mediated diseases, including asthma. 1 “To address the significant unmet need for ...