Advances in knowledge about the pathogenesis of rheumatoid arthritis (RA) have led to the development of targeted therapies that act directly on inflammatory cytokines or cell-surface molecules.

CD23 + CD21 hi B cells were found to be involved in arthritis progression in TNF-transgenic mice from the earliest stages of the disease A study exploring the pathogenesis of rheumatoid arthritis ...

Like cytokines and other mediators of the immune system, MPs have pleiotropic actions and can affect multiple steps in disease pathogenesis ... or arthrocentesis in RA. Selective therapies ...

RA, an autoimmune disorder affecting 1-2% of ... factor- (TNF- ) and interleukin-1 (IL-1), play a critical role in the pathogenesis of this disorder. IL-1-receptor antagonist (IL-1Ra) is produced ...

Recent research explores how gut microbiome imbalances contribute to rheumatoid arthritis, and how dietary interventions could be key to reducing inflammation and improving patient outcomes.