Patients with rheumatoid arthritis are associated with an increased risk for heart failure, particularly heart failure with preserved ejection fraction.

An increasing body of evidence pinpoints that epigenetic modifications play an important role in the regulation of RA pathogenesis. Epigenetics causes heritable phenotype changes that are not ...

In this review we describe RA pathogenesis with a focus on knowledge obtained from patients with arthralgia, pre-RA and recently diagnosed RA. Connections are proposed between altered immune cells, ...

We now know that over 100 loci are associated with RA risk. Because genetic information implies a clear causal relationship to the disease, research into the pathogenesis of RA should be promoted.

However, DcR3 might also contribute to the pathogenesis of RA by downregulating the apoptotic pathways of inflammatory cells, which are mediated by Fas ligand. In fact, defective clearance of ...

RA, an autoimmune disorder affecting 1-2% of ... factor- (TNF- ) and interleukin-1 (IL-1), play a critical role in the pathogenesis of this disorder. IL-1-receptor antagonist (IL-1Ra) is produced ...

Like cytokines and other mediators of the immune system, MPs have pleiotropic actions and can affect multiple steps in disease pathogenesis ... or arthrocentesis in RA. Selective therapies ...

CD23 + CD21 hi B cells were found to be involved in arthritis progression in TNF-transgenic mice from the earliest stages of the disease A study exploring the pathogenesis of rheumatoid arthritis ...

the contribution of epigenetic regulation to the pathogenesis of SS and RA is at present poorly understood. This review attempts to shed light from a critical point of view on the identification of ...

83{at}163.com; Professor Jinxiang Han; sams-h2016{at}163.com Objective The aim of this study was to investigate the role of CD109 in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and ...

Recent research explores how gut microbiome imbalances contribute to rheumatoid arthritis, and how dietary interventions could be key to reducing inflammation and improving patient outcomes.