At present there is no broad consensus on whether the apparent 'preoccupation' of the TCR repertoire with MHC molecules is due to the coligation of CD4 or CD8 coreceptors and the TCR by MHC ...

αβ and γδ T cells have distinct functions and reside in different locations yet they originate from a common precursor in the thymus ... to the double-positive (CD4 + CD8 +) stage.