Trisomy 21 is now accepted to be the major cause of ... because mice carrying translocations from MMU16 display symptoms more like human DS than mice carrying translocations of MMU10 or MMU17.

Fluorescence in situ hybridization (FISH) of interphase nuclei from a fetus has been used to diagnose trisomy 21. In each cell, there are two green spots (LSI 13 SpectrumGreen probe, Vysis ...