Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

and tumor-associated macrophages as well as uncovering crucial adaptive T cell regulation pathways in cancer. Using murine genetic cancer models and patient tumor specimens, we were the first to ...

The Arkansas Integrative Metabolic Research Center will host Jeffrey Rathmell, a professor of pathology, microbiology and immunology from Vanderbilt University on Wednesday, Jan. 22.

Discover how immune iFRET biomarkers offer new insights into predicting response to neoadjuvant melanoma therapy, driving ...

The study introduces an innovative tracer targeting CD163, a molecular receptor on tumor-associated macrophages—immune cells that support tumor growth and protection. The tracer is based on ...

25, a research team reported the development of an innovative intelligent light-guided biohybrid system, the CTPA/siCSF1R system, to target tumor-associated macrophages (TAMs), thus enabling ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that ...

The biotech’s approach to fighting cancer is based around “repolarising” tumour-associated macrophages (TAMs) using small molecule drugs so that they no longer suppress the immune system ...

Cancer-associated fibroblasts (CAFs), distinguished ... the interactions between CAFs and innate immune cells (such as macrophages, neutrophils, mast cells, etc.) as well as adaptive immune ...