通过线粒体转移,癌细胞不仅实现了对T细胞功能的精确抑制,还为其免疫逃逸增加了一道屏障。该研究进一步指出,这种机制与免疫治疗效果不佳密切相关,尤其是在携带大量mtDNA突变的患者中,免疫检查点抑制剂的疗效显著降低。
Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune ...
在肿瘤的发生和转移过程中,炎症扮演着至关重要的角色。最新研究表明,炎症不仅是肿瘤微环境(Tumor Microenvironment, TME)的关键组成部分,还直接影响肿瘤的生长与转移路径。因此,在深入肿瘤相关研究时,探索炎症的不同模式以及其在肿瘤微环境中的作用,成为了不可或缺的重要步骤。 为了更好地理解这一复杂的关系,丁香园与中国免疫学会青工委将于1月22日晚20:00举办「青云免疫论坛」第1 ...
Researchers at the University of Pennsylvania have introduced lab-engineered small extracellular vesicles to target tumors in ...
The tissue adjacent to a tumor behaves differently than areas farther away. The tumor's cancerous cells influence their ...
The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing ...
A research team made a pivotal discovery in the field of cancer immunotherapy. The team identified a specific population of immune cells that play a critical role in successful treatment of relapsed ...
Cancer remains one of the most complex diseases, with its diverse molecular profiles and cellular compositions posing ...
A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical ...