The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout ... species. The well described syntenic relationships between human and mouse genomes ...

For example, knockout mice have been crucial for studying and modeling different types of cancer, obesity, heart disease, ...