Scientists in China have manipulated embryonic stem cells to create laboratory mice with two male parents that managed to ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

In the Transgenic and Knockout Core, transgenic mice are generated by pronuclear microinjection of foreign DNA fragments into one-cell-stage mouse embryos. On average, it takes about three to four ...

Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout ... species. The well described syntenic relationships between human and mouse genomes ...

The Transgenic and Knockout Core can develop mice with targeted mutations in the entire mouse or in specific tissues or cell types. It normally takes about a year to generate a gene-targeted mouse.

For example, knockout mice have been crucial for studying and modeling different types of cancer, obesity, heart disease, ...

Mutations in humans cause type 3 haemochromatosis and a targeted mutation in mice leads to iron overload with a similar phenotype. We have previously described the generation of a complete ...

As primary spermatocytes of double knockout mice stop their differentiation in pachytene ... Based on these results we can conclude that iDKO causes perturbance in different testicular cell types: ...