Nature12y
Activation of ERBB Receptors
The ERBB receptors are a group of receptor tyrosine kinases (RTKs ... and all except ERBB3 have relatively active kinase domains. Although ERBB2 is minimally active in ligand binding, it is ...
ophthalmologytimes8d
Tyrosine kinase inhibitor: An alternative treatment for non–small-cell lung cancer metastasis to the choroid
Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical ...
BioWorld8d
PTP1B allosteric inhibitor enhances glucose uptake in insulin resistance models
Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...
Nature1mon
Epidermal growth factor receptor mutations in lung cancer
Figure 5: Cell-survival pathways downstream of activated erbB receptor tyrosine kinases. The Ras–MAPK (mitogen-activated protein kinase) pathway is another important cell-proliferation pathway ...