the most studied member of the type I receptor tyrosine kinase family, is present in up to 25% of women with breast cancer and is associated with a poor prognosis. EGFR (ErbB1), another member of ...

Members of the RTK family include, among others, the insulin and insulin-like growth factor-1 (IGF1 ... We are also studying the molecular mechanisms by which JAK2, a member of the Janus kinase family ...

Background Tyrosine kinase 2 (Tyk2) is a member of the JAK family that phosphorylates STAT proteins downstream of the IL-12, IL-23 and the Type I interferon receptor. Tyk2 genetic variants have been ...