We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Degradation: Damaged proteins are broken down via the ubiquitin-proteasome system or lysosomes. ・Aggregate clearance: Autophagy eliminates clusters of misfolded proteins. These systems degrade ...